Nastaran Salehi Marzijarani

A kinase-cGAS cascade to synthesize a therapeutic STING activator

John A. McIntosh, Zhijian Liu, Brian M. Andresen et al. · Nature · 2022 · 125 citations

Signal Transduction, Biochemistry, Receptor Tyrosine Kinase +5

Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan

Wai Ling Cheung‐Lee, Joshua N. Kolev, John A. McIntosh et al. · Angewandte Chemie International Edition · 2024 · 51 citations · Full text

Key Intermediate, Engineering, Enzyme Stability +16

Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454

Tamas Benkovics, Feng Peng, Eric M. Phillips et al. · Journal of the American Chemical Society · 2022 · 45 citations

Combinatorial Chemistry, Bioorganic Chemistry, Engineering +20

Manufacturing Process Development for Belzutifan, Part 3: Completing a Streamlined Through-Process with a Safe and Scalable Oxidation

Zhiwei Chen, Nastaran Salehi Marzijarani, Scott Quirie et al. · Organic Process Research & Development · 2021 · 27 citations

Scalable Oxidation, Engineering, Industrial Engineering +16

Manufacturing Process Development for Belzutifan, Part 4: Nitrogen Flow Criticality for Transfer Hydrogenation Control

Nastaran Salehi Marzijarani, Adam J. Fine, Stephen M. Dalby et al. · Organic Process Research & Development · 2021 · 26 citations

Process Integration, Engineering, Hydrogen Production +18