Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard, Lindsey B. Rosen, Qian Zhang, +81

Science

Viral DiagnosticsImmunodeficienciesViral ImmunityImmunologyViral Pathogenesis +17

Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity

Anne Puel, Sophie Cypowyj, Jacinta Bustamante, +21

Science

ImmunodeficienciesImmunologyDermatologyImmunotherapyInflammation +15

Gain-of-function human <i>STAT1</i> mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

Luyan Liu, Satoshi Okada, Xiao‐Fei Kong, +58

The Journal of Experimental Medicine

Microbial PathogensImmunodeficienciesInnate Immune SystemImmunologyImmune Regulation +19

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Paul Bastard, Adrian Gervais, Tom Le Voyer, +137

Science Immunology

Impairment of immunity to <i>Candida</i> and <i>Mycobacterium</i> in humans with bi-allelic <i>RORC</i> mutations

Satoshi Okada, Janet Markle, Elissa K. Deenick, +48

Science

Deep Dermatophytosis and Inherited CARD9 Deficiency

Fanny Lanternier, Saad Pathan, Quentin B. Vincent, +29

New England Journal of Medicine

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

Alexandra Y. Kreins, Michael J. Ciancanelli, Satoshi Okada, +51

The Journal of Experimental Medicine

Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1

Paul Bastard, Elizaveta Orlova, Leila Sozaeva, +62

The Journal of Experimental Medicine

Aire SufferLong CovidAutoimmune DiseaseIntensive Care UnitImmunodeficiencies +12

Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species–induced meningoencephalitis, colitis, or both

Fanny Lanternier, Seyed Alireza Mahdaviani, Elisa Barbati, +33

Journal of Allergy and Clinical Immunology

PathogenesisGenetic EpidemiologyPathologyMedicineHealthy Children +1

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

Rubén Martínez‐Barricarte, Janet Markle, S. Cindy, +49

Science Immunology