Jane Owens

A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

Michael St. Andre, M. Catherine Johnson, Prashant Bansal et al. · Skeletal Muscle · 2017 · 100 citations · Full text

Medicine, Immunology, Pharmacotherapy +17

Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments

Shelli Schomaker, David M. Potter, Roscoe L. Warner et al. · PLoS ONE · 2020 · 64 citations · Full text

Medicine, Biochemistry, Enzymology +16

Distinct protein degradation profiles are induced by different disuse models of skeletal muscle atrophy

Peter Bialek, Carl Morris, Jascha Parkington et al. · Physiological Genomics · 2011 · 59 citations

Life Sciences, Biochemistry, Molecular Biology +17

Report of a TREAT-NMD/World Duchenne Organisation Meeting on Dystrophin Quantification Methodology

Annemieke Aartsma‐Rus, Jennifer E. Morgan, Pallavi Lonkar et al. · Journal of Neuromuscular Diseases · 2019 · 57 citations · Full text

Pharmacy, Molecular Medicine, Translational Sciences +17

Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody

James R. Apgar, Michelle Mader, Rita Agostinelli et al. · mAbs · 2016 · 53 citations · Full text

Pharmacy, Biotechnology, Molecular Biology +17