James R. Apgar - Concepedia

Author

James R. Apgar

Also Known As

Apgar, James; Lessard, Philip; Raab, Michael R.; Shen, Binzhang; Lazar, Gabor; de la Vega, Humberto, James Apgar, James R. Apgar

Publications

804

Citations

H-Index

Concepts

All Affiliations

Pfizer (United States)IIT@MIT Pfizer (Ireland)Agrivida (United States)

About

James R. Apgar is an author at Pfizer (United States) specializing in medicine, protein engineering, and molecular biology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	6	6	472
2	Engineering	3	3	151
3	Natural Sciences	3	3	309
4	Health Sciences	1	1	85
5	Biochemistry	1	1	80

James R. Apgar

Publications

799

Citations

H-Index

Page 1

	Year	Citations
<scp>AB</scp> ‐Bind: Antibody binding mutational database for computational affinity predictions Sarah Sirin, James R. Apgar, Eric M. Bennett, Protein Science Computational Affinity PredictionsImmunologyMolecular BiologyAnalytical UltracentrifugationSystems Pharmacology	2015	180
Establishing <i>in vitro in vivo</i> correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics Lindsay B. Avery, Jason Wade, Mengmeng Wang, mAbs Immunocytochemical TechniqueImmunologyPathologyImmunotherapyImmunological Biomarkers	2017	97
Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer Adam Root, Wei Cao, Bilian Li, Antibodies	2016	92
Engineering a thermoregulated intein-modified xylanase into maize for consolidated lignocellulosic biomass processing Binzhang Shen, Xueguang Sun, Xiao Zuo, Nature Biotechnology Biomass ConversionBiomanufacturingBioenergyEngineeringLignin	2012	85
Modeling Backbone Flexibility to Achieve Sequence Diversity: The Design of Novel α-Helical Ligands for Bcl-xL Xiaoran Fu, James R. Apgar, Amy E. Keating Journal of Molecular Biology Novel α-Helical LigandsBackbone FlexibilityMolecular DiversityBiochemistryNatural Sciences	2007	80
Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody James R. Apgar, Michelle Mader, Rita Agostinelli, mAbs Immunocytochemical TechniqueImmunologyTraditional Cdr-graftingMolecular BiologyStructure-guided Humanization	2016	49
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design James R. Apgar, Amy Tam, Rhady Sorm, PLoS ONE EngineeringNegative Charge PatchesBiomedical EngineeringProtein NanoparticlesProtein Purification	2020	48
Predicting helix orientation for coiled‐coil dimers James R. Apgar, Karl N. Gutwin, Amy E. Keating Proteins Structure Function and Bioinformatics	2008	34
Low-data interpretable deep learning prediction of antibody viscosity using a biophysically meaningful representation K. Brajesh, James R. Apgar, Eric M. Bennett Scientific Reports	2023	31
Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease Xiaotian Zhong, Srinath Jagarlapudi, Yan Weng, Journal of Biological Chemistry	2020	28

Page 1