5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity

Julie Vincent, Grégoire Mignot, Fanny Chalmin, +7

Cancer Research

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

Mélanie Bruchard, Grégoire Mignot, Valentin Dérangère, +12

Nature Medicine

InflammationTumor BiologyCancer ImmunosurveillanceMedicineNlrp3 Inflammasome +6

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

Mélanie Bruchard, Cédric Rébé, Valentin Dérangère, +12

Nature Immunology

Transcriptional RegulationSignal TransductionSignaling PathwayImmunologyReceptor (Biochemistry) +6

Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression

Fanny Chalmin, Grégoire Mignot, Mélanie Bruchard, +15

Immunity

InflammationEctonucleotidase ExpressionTranscriptional RegulationCytokineSignal Transduction +7

Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Emeric Limagne, Romain Euvrard, Marion Thibaudin, +12

Cancer Research

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

Angélique Chevriaux, Thomas Pilot, Valentin Dérangère, +5

Frontiers in Cell and Developmental Biology

HSP70 is a negative regulator of NLRP3 inflammasome activation

Pierre Martine, Angélique Chevriaux, Valentin Dérangère, +4

Cell Death and Disease

ImmunologyImmune RegulationCell DeathNod-leucine Rich RepeatInnate Immunity +21

Monitoring HSP70 exosomes in cancer patients’ follow up: a clinical prospective pilot study

Gaëtan Chanteloup, Marine Cordonnier, Nicolás Isambert, +29

Journal of Extracellular Vesicles

Induction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor α Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages

Cédric Rébé, Magalie Raveneau, Angélique Chevriaux, +13

Circulation Research

Fluorouracil and bevacizumab plus anakinra for patients with metastatic colorectal cancer refractory to standard therapies (IRAFU): a single-arm phase 2 study

Nicolás Isambert, Alice Hervieu, Cédric Rébé, +10

OncoImmunology