Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

Alexia K. Cotte, Virginie Aires, Maxime Fredon, +9

Nature Communications

Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Emeric Limagne, Romain Euvrard, Marion Thibaudin, +12

Cancer Research

Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination

M. Grapin, Corentin Richard, Emeric Limagne, +10

Journal for ImmunoTherapy of Cancer

MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

Emeric Limagne, Lisa Nuttin, Marion Thibaudin, +24

Cancer Cell

Cancer ImmunosurveillanceOncologyMedicineImmunologyImmune Checkpoint Inhibitor +9

Tim-3/galectin-9 pathway and mMDSC control primary and secondary resistances to PD-1 blockade in lung cancer patients

Emeric Limagne, Corentin Richard, Marion Thibaudin, +6

OncoImmunology

Secondary ResistancesPd-1 BlockadeImmunologyImmunoeditingPathology +14

Trifluridine/Tipiracil plus Oxaliplatin Improves PD-1 Blockade in Colorectal Cancer by Inducing Immunogenic Cell Death and Depleting Macrophages

Emeric Limagne, Marion Thibaudin, Lisa Nuttin, +7

Cancer Immunology Research

Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation

Emeric Limagne, Marion Thibaudin, Romain Euvrard, +11

Cell Reports

T-regulatory CellImmunologyCell ProliferationCancer BiologyTumor Biology +14

Follicular helper-T cells restore CD8⁺-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy

Julie Niogret, Hélène Berger, Cédric Rébé, +15

Journal for ImmunoTherapy of Cancer

First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial

Marion Thibaudin, Jean-David Fumet, Benoist Chibaudel, +21

Nature Medicine

Tumor BiologyMedicineImmunologyColorectal CancerPathology +12

Targeting PD-L1 and TIGIT could restore intratumoral CD8 T cell function in human colorectal cancer

Marion Thibaudin, Emeric Limagne, Léa Hampe, +3

Cancer Immunology Immunotherapy

Cancer ImmunosurveillanceMedicineImmunologyColorectal CancerImmune Checkpoint Inhibitor +4