Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness

Hitoshi Takizawa, Kristin Fritsch, Larisa V. Kovtonyuk, +10

Cell stem cell

InflammationT-regulatory CellInnate Immune SystemImmunologyHematopoietic Stem Cells +5

Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells

Puneet Agarwal, Stephan Isringhausen, Hui Li, +6

Cell stem cell

Developmental BiologyCell RegulationMedicineStem Cell ResearchCell Proliferation +8

Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy

Álvaro Gomariz, Patrick M. Helbling, Stephan Isringhausen, +11

Nature Communications

Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness

Stephan Isringhausen, YeVin Mun, Larisa V. Kovtonyuk, +10

The Journal of Experimental Medicine

ImmunologyImmunologic MechanismImmunotherapyViral PersistenceBone Marrow Failure +17

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice

Yoshito Yamada, Tuan T. Nguyen, Daniela Impellizzieri, +8

Nature Communications

Multiparametric imaging reveals that mitochondria‐rich intercalated cells in the kidney collecting duct have a very high glycolytic capacity

Susan Ghazi, Soline Bourgeois, Álvaro Gomariz, +8

The FASEB Journal

High Glycolytic CapacityMitochondrial BiologyMrc FamilyCellular PhysiologyCell Imaging +24

Modality attention and sampling enables deep learning with heterogeneous marker combinations in fluorescence microscopy

Álvaro Gomariz, Tiziano Portenier, Patrick M. Helbling, +4

Nature Machine Intelligence

Fluorescence MicroscopyConvolutional Neural NetworkSystems BiologyEngineeringDeep Learning +13

<i>In-Vivo</i>Quantitative Image Analysis of Age-Related Morphological Changes of<i>C. elegans</i>Neurons Reveals a Correlation between Neurite Bending and Novel Neurite Outgrowths

M. W. Hess, Álvaro Gomariz, Orçun Göksel, +1

eNeuro