David G. Williams

ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies

Francesca Zammarchi, Simon Corbett, Lauren Adams et al. · Blood · 2018 · 181 citations · Full text

Pharmacy, Oncology, Pharmaceutics +13

Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

Arnaud Tiberghien, Jean-Noel Levy, Luke A. Masterson et al. · ACS Medicinal Chemistry Letters · 2016 · 167 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody–Drug Conjugates Using Click Cycloaddition Chemistry

Michael Pete VanBrunt, Kurt Shanebeck, Zachary Caldwell et al. · Bioconjugate Chemistry · 2015 · 142 citations

Pharmacy, Medicinal Chemistry, Oncology +17

Virus infection induces redistribution and membrane localization of the nuclear antigen La (SS-B): a possible mechanism for autoimmunity.

C. Baboonian, Patrick J Venables, Jayaum S. Booth et al. · PubMed · 1989 · 137 citations

Life Sciences, Immunology, Pathology +12

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

John A. Hartley, Michael Flynn, John P. Bingham et al. · Scientific Reports · 2018 · 129 citations · Full text

Medicine, Oncology, Pharmacology +14