Edwin J. Schweiger

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Nicholas D. P. Cosford, Lida Tehrani, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2002 · 400 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Cyclic conjugated enediynes related to calicheamicins and esperamicins: calculations, synthesis, and properties

K.C. Nicolaou, Yuki Ogawa, Guido Zuccarello et al. · Journal of the American Chemical Society · 1988 · 286 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

[3H]-Methoxymethyl-MTEP and [3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

Nicholas D. P. Cosford, Jeffrey Roppe, Lida Tehrani et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 146 citations · Full text

Medicine, Neuroscience, Pharmacology +11

A New Class of DNA‐Cleaving Molecules: pH‐Dependent DNA Cleavage by Propargylic and Allenic Sulfones

K. C. Nicolaou, G. SKOKOTAS, Peter E. Maligres et al. · Angewandte Chemie International Edition in English · 1989 · 79 citations

Natural Sciences, Chemistry, Molecular Biology +11

5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3′-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity

Jeffrey Roppe, Bowei Wang, Dehua Huang et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 46 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14