A New Class of DNA‐Cleaving Molecules: pH‐Dependent DNA Cleavage by Propargylic and Allenic Sulfones

Abstract

DNA-cleaving agents are of considerable interest in molecular biology and pharmaceutical chemistry. The Garrett–Braverman reaction sequence has now been utilized as a basis for developing the title compounds; l–3 are examples. They are capable of cleaving ϕX174 DNA in a pH-dependent reaction with maximal activity at pH 8.5.