Concepedia

A New Class of DNA‐Cleaving Molecules: pH‐Dependent DNA Cleavage by Propargylic and Allenic Sulfones

K. C. Nicolaou, G. SKOKOTAS, Peter E. Maligres, Guido Zuccarello, Edwin J. Schweiger, Kazunobu Toshima, Sebastian Wendeborn

Angewandte Chemie International Edition in English · 1989 · 79 citations · 14 references

DOI

Concepts

Abstract

DNA-cleaving agents are of considerable interest in molecular biology and pharmaceutical chemistry. The Garrett–Braverman reaction sequence has now been utilized as a basis for developing the title compounds; l–3 are examples. They are capable of cleaving ϕX174 DNA in a pH-dependent reaction with maximal activity at pH 8.5.

References

14

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DNA cleavage by a synthetic mimic of the calicheamicin-esperamicin class of antibiotics

K. C. Nicolaou, Yoshihiro Ogawa, Guido Zuccarello et al. · Journal of the American Chemical Society · 1988 · 122 citations

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