High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

Dominic Hoepfner, Stephen B. Helliwell, Heather Sadlish, +32

Microbiological Research

Prokaryotic SystemProtein AssemblyStructural BioinformaticsProtein FoldingNatural Sciences +9

Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti‐Cancer Properties

Philipp Krastel, Silvio Roggo, Markus Schirle, +19

Angewandte Chemie International Edition

The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase

David Estoppey, Chia Min Lee, Marco Janoschke, +15

Cell Reports

Dengue Virus ReplicationDengue VirusSynthetic VirologyMolecular BiologyViral Structural Protein +19

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics

Ulrich Elling, Reiner Wimmer, Andreas Leibbrandt, +29

Nature

BioinformaticsKnockout MouseInduced Pluripotent Stem CellFunctional GenomicsDevelopmental Biology +9

Decatransin, a novel natural product inhibiting protein translocation at the Sec61/SecY translocon

Tina Junne, Joanne Wong, Christian Studer, +21

Journal of Cell Science

Identification of Elongation Factor G as the Conserved Cellular Target of Argyrin B

Beat Nyfeler, Dominic Hoepfner, Deborah Palestrant, +26

PLoS ONE

Molecular BiologyCytoskeletonCell GrowthCellular PhysiologyCyclic Octapeptides +17

Identification and Evaluation of Novel Acetolactate Synthase Inhibitors as Antifungal Agents

Daryl L. Richie, Katherine V. Thompson, Christian Studer, +16

Antimicrobial Agents and Chemotherapy

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells

David Estoppey, Jeffrey Hewett, Chantale T. Guy, +25

Scientific Reports

IRF2 is a master regulator of human keratinocyte stem cell fate

Nicolas Mercado, Gabi Schutzius, Christian Kolter, +23

Nature Communications

Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol

Yue Fu, David Estoppey, Silvio Roggo, +17

Nature Communications