Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor

Holger Raviol, Heather Sadlish, Fernanda Rodriguez, +2

The EMBO Journal

Protein FunctionBiochemistryNatural SciencesMolecular BiologyChaperone Network +6

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

Dominic Hoepfner, Stephen B. Helliwell, Heather Sadlish, +32

Microbiological Research

Prokaryotic SystemProtein AssemblyStructural BioinformaticsProtein FoldingNatural Sciences +9

Sequential triage of transmembrane segments by Sec61α during biogenesis of a native multispanning membrane protein

Heather Sadlish, David Pitonzo, Arthur E. Johnson, +1

Nature Structural & Molecular Biology

Protein SecretionNatural SciencesTransmembrane SegmentsMolecular BiologyMembrane Biology +7

Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity

Benjamin Vincent, Daniel F. Tardiff, Jeff S. Piotrowski, +15

Cell Reports

Evidence for a Functionally Relevant Rocaglamide Binding Site on the eIF4A–RNA Complex

Heather Sadlish, Gabriela Galicia-Vázquez, C. Paris, +13

ACS Chemical Biology

Systems BiologyEngineeringBiochemistryNatural SciencesRna Structure Prediction +10

Hsp110 Chaperones Regulate Prion Formation and Propagation in S. cerevisiae by Two Discrete Activities

Heather Sadlish, Heike Rampelt, James Shorter, +4

PLoS ONE

The Novolactone Natural Product Disrupts the Allosteric Regulation of Hsp70

Amr Hassan, C.A. Kirby, Wenlai Zhou, +21

Chemistry & Biology

BiosynthesisProtein FunctionBiochemistryAllosteric RegulationNatural Sciences +6

Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas

Wayne F. Flintoff, Heather Sadlish, Richard Görlick, +2

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Tumor BiologyPathologyOsteocalcinFunctional AnalysisMedicine +3

Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function

Heather Sadlish, Frederick M. Williams, Wayne F. Flintoff

Biochemical Journal

Protein FunctionSignal TransductionBiochemistryReduced Folate CarrierNatural Sciences +13

Mutations in the reduced-folate carrier affect protein localization and stability

Heather Sadlish, Richard C. Murray, Frederick M. Williams, +1

Biochemical Journal

BiochemistryGenetic DisorderNatural SciencesGeneticsBiochemical Genetics +13