Sander Mertens

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Carla S. Veríssimo, René Overmeer, Bas Ponsioen et al. · eLife · 2016 · 270 citations · Full text

Medicine, Cancer Biology, Oncology +17

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Bas Ponsioen, Jasmin B. Post, Julian R. Buissant des Amorie et al. · Nature Cell Biology · 2021 · 143 citations · Full text

Medicine, Cell Biology, Oncology +16

DNA damage induces p53-independent apoptosis through ribosome stalling

N. Boon, Rafaela A. Oliveira, Pierre-René Körner et al. · Science · 2024 · 128 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

Sander Mertens, Maarten A. Huismans, Carla S. Veríssimo et al. · Cell Reports · 2023 · 69 citations · Full text

Medicine, Oncology, Pharmacology +15