Discovery of Highly Selective and Orally Active Lysophosphatidic Acid Receptor-1 Antagonists with Potent Activity on Human Lung Fibroblasts

Yimin Qian, Matthew J. Hamilton, Achyutharao Sidduri, +18

Journal of Medicinal Chemistry

ImmunologyPharmacotherapyLpa StimulationInflammationMedicinal Chemistry +18

Polyglutamine- and Temperature-Dependent Conformational Rigidity in Mutant Huntingtin Revealed by Immunoassays and Circular Dichroism Spectroscopy

Valentina Fodale, Natalie C. Kegulian, Margherita Verani, +15

PLoS ONE

Pyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors

Fernando Padilla, Niala Bhagirath, Shaoqing Chen, +28

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +10

Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B

Ryan C. Schoenfeld, David L. Bourdet, Ken A. Brameld, +15

Journal of Medicinal Chemistry

Hepatitis C VirusMolecular BiologyAntiviral DrugMedicinal ChemistryViral Hepatitis +14

De Novo Fragment Design: A Medicinal Chemistry Approach to Fragment-Based Lead Generation

Francisco X. Talamás, Gloria Ao-Ieong, Ken A. Brameld, +14

Journal of Medicinal Chemistry

Combinatorial ChemistryBioorganic ChemistryHit IdentificationStructural BioinformaticsMolecular Biology +22

2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression

David S. Carter, Haiying Cai, Eun Kyung Lee, +5

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPsychiatry2-Substituted N-aryl PiperazinesPsychotropic MedicationPharmacology +9

Discovery of <i>N</i>-[4-[6-<i>tert</i>-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1<i>H</i>-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase

Francisco X. Talamás, Sarah C. Abbot, Shalini Anand, +25

Journal of Medicinal Chemistry

Quinoline 41Bioorganic ChemistryViral Polymerase StructurePotent InhibitorAntiviral Drug +15

Synthesis of ceratinamine and moloka'iamine: Antifouling agents from the marine sponge Pseudoceratina purpurea

Ryan C. Schoenfeld, Bruce Ganem

Tetrahedron Letters

Marine BiotechnologyEngineeringBiochemistryAntiparasitic AgentNatural Sciences +10

Cytotoxic, antifouling bromotyramines: A synthetic study on simple marine natural products and Their analogues

Ryan C. Schoenfeld, Susan Conova, Daniel Rittschof, +1

Bioorganic & Medicinal Chemistry Letters

Their AnaloguesBiochemistryBioassay-guided IsolationPharmacologySynthetic Study +1

Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors

Linda Maria Bannwart, David S. Carter, Haiying Cai, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineNovel 3,3-Disubstituted PyrrolidinesPsychopharmacologyNeuropharmacology +5