Mariah L. Arral

The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs

Samuel T. LoPresti, Mariah L. Arral, Namit Chaudhary et al. · Journal of Controlled Release · 2022 · 260 citations · Full text

Pharmacy, Bioengineering, Pharmaceutics +17

Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer

Jilian R. Melamed, Saigopalakrishna S. Yerneni, Mariah L. Arral et al. · Science Advances · 2023 · 190 citations · Full text

Pharmacy, Biotechnology, Pharmaceutics +17

Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d

Namit Chaudhary, Lisa N. Kasiewicz, Alexandra N. Newby et al. · Nature Biomedical Engineering · 2024 · 99 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery

Jilian R. Melamed, Khalid A. Hajj, Namit Chaudhary et al. · Journal of Controlled Release · 2021 · 90 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

The mixing method used to formulate lipid nanoparticles affects mRNA delivery efficacy and organ tropism

Daria M. Strelkova Petersen, Namit Chaudhary, Mariah L. Arral et al. · European Journal of Pharmaceutics and Biopharmaceutics · 2023 · 70 citations · Full text

Pharmacy, Bioengineering, Biotechnology +17