The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

Paul J. Emmerson, Feng Wang, Yong Du, +21

Nature Medicine

Metabolic SyndromeEnergy MetabolismBiochemistryG Protein-coupled ReceptorMedicine +10

Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex

Ian N. Foltz, Sylvia Hu, Chadwick King, +23

Science Translational Medicine

Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors

Claudia Erbel-Sieler, Carol A. Dudley, Yudong Zhou, +7

Proceedings of the National Academy of Sciences

GeneticsSocial SciencesTranscriptional RegulationLaboratory MiceRegulatory Abnormalities +20

FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation

Xinle Wu, Hongfei Ge, Bryan D. Lemon, +8

Journal of Biological Chemistry

The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice

Andrew A. Pieper, Xinle Wu, Tina W. Han, +8

Proceedings of the National Academy of Sciences

Co-receptor Requirements for Fibroblast Growth Factor-19 Signaling

Xinle Wu, Hongfei Ge, Jamila Gupte, +13

Journal of Biological Chemistry

Signaling property study of adhesion G‐protein‐coupled receptors

Jamila Gupte, Gayathri Swaminath, Jay Danao, +3

FEBS Letters

Tested Adhesion GpcrsCell AdhesionCellular PhysiologyMolecular PharmacologyCell Signaling +15

Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)

Xinle Wu, Hongfei Ge, Bryan D. Lemon, +8

Proceedings of the National Academy of Sciences

Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in <i>ob/ob</i> mice

Xinle Wu, Hongfei Ge, Bryan D. Lemon, +7

Proceedings of the National Academy of Sciences

Glucose HomeostasisMetabolic RemodelingCholangiopathiesSelective ActivationMetabolic Syndrome +23

C-terminal Tail of FGF19 Determines Its Specificity toward Klotho Co-receptors

Xinle Wu, Bryan D. Lemon, Xiaofan Li, +9

Journal of Biological Chemistry