Identification and Characterization of MEDI4736, an Antagonistic Anti–PD-L1 Monoclonal Antibody

Ross Stewart, Michelle Morrow, Scott A. Hammond, +18

Cancer Immunology Research

ImmunologyImmunoeditingImmunologic MechanismImmunotherapyTumor Biology +18

Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects

Kannan Gunasekaran, Martin Pentony, Min Shen, +11

Journal of Biological Chemistry

EngineeringImmunoengineeringFc Heterodimer FormationElectrostatic Steering EffectsSynthetic Biology +9

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

Elizabeth A. Killion, Jinghong Wang, Junming Yie, +22

Science Translational Medicine

Glp-1r AgonistsAnti-obesity EffectsImmunologyAnti-gipr AntibodiesPharmacotherapy +18

Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex

Ian N. Foltz, Sylvia Hu, Chadwick King, +23

Science Translational Medicine

Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway

Ian N. Foltz, John C. Lee, Peter R. Young, +1

Journal of Biological Chemistry

Interleukin-4 ActivateImmunologyHemopoietic Growth FactorsCell ProliferationOxidative Stress +18

Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity

Jonathan D. Graves, Jennifer J. Kordich, Tzu-Hsuan Huang, +15

Cancer Cell

Antitumor ActivityG Protein-coupled ReceptorMedicineFunctional SelectivityApoptosis +7

Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2

Athena Sudom, Santosh Talreja, Jean Danao, +16

Journal of Biological Chemistry

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

Sandra L. Ross, Lynn Tran, Aaron Winters, +14

Cell Metabolism

Bioorganic ChemistryBiochemistryNatural SciencesMolecular MechanismMolecular Biology +4

TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function

Qingwen Cheng, Jean Danao, Santosh Talreja, +11

Journal of Biological Chemistry

Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease

Daniel C. Ellwanger, Shoutang Wang, Simone Brioschi, +16

Proceedings of the National Academy of Sciences