Mark Ruppen

A continuous assay for DNA cleavage: The application of “break lights” to enediynes, iron-dependent agents, and nucleases

John Biggins, James R. Prudent, David J. Marshall et al. · Proceedings of the National Academy of Sciences · 2000 · 111 citations

Life Sciences, Biochemistry, Molecular Biology +14

PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors

Ker Yu, Judy Lucas, Tianmin Zhu et al. · Cancer Biology & Therapy · 2005 · 65 citations · Full text

Medicine, Oncology, Pharmacology +15

Hybrid Inhibitors of Phosphatidylinositol 3-Kinase (PI3K) and the Mammalian Target of Rapamycin (mTOR): Design, Synthesis, and Superior Antitumor Activity of Novel Wortmannin−Rapamycin Conjugates

Semiramis Ayral‐Kaloustian, Jianxin Gu, Judy Lucas et al. · Journal of Medicinal Chemistry · 2009 · 47 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Pegylated Wortmannin and 17-Hydroxywortmannin Conjugates as Phosphoinositide 3-Kinase Inhibitors Active in Human Tumor Xenograft Models

Tianmin Zhu, Jianxin Gu, Ker Yu et al. · Journal of Medicinal Chemistry · 2006 · 42 citations

Medicine, Oncology, Pharmacology +12

Lipase-Catalyzed Regioselective Esterification of Rapamycin:  Synthesis of Temsirolimus (CCI-779)

Jianxin Gu, Mark Ruppen, Ping Cai · Organic Letters · 2005 · 40 citations

Natural Sciences, Chemistry, Medicinal Chemistry +15