Concepedia

Lipase-Catalyzed Regioselective Esterification of Rapamycin:  Synthesis of Temsirolimus (CCI-779)

Jianxin Gu, Mark Ruppen, Ping Cai

Organic Letters · 2005 · 40 citations · 14 references

DOI

Concepts

Abstract

A lipase-catalyzed acylation of the immunosuppressant rapamycin with complete regioselectivity is described. The method was successfully applied to the synthesis of 42-hemiesters and temsirolimus (CCI-779), an investigational oncology drug.[reaction: see text]

References

14

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