Emily R. Olson

THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL

Angela C. Doran, R. Scott Obach, Bill J. Smith et al. · Drug Metabolism and Disposition · 2004 · 440 citations

Medicine, Pharmacokinetics, Pharmacology +16

In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation

Björn Bauer, Xiaodong Yang, Anika M. S. Hartz et al. · Molecular Pharmacology · 2006 · 189 citations

Medicine, Pharmacology, Pharmacotherapy +16

Pharmacokinetics and Pharmacodynamics of Seven Opioids in P-Glycoprotein-Competent Mice: Assessment of Unbound Brain EC50,u and Correlation of in Vitro, Preclinical, and Clinical Data

J. Cory Kalvass, Emily R. Olson, Michael P. Cassidy et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 161 citations

Medicine, Pharmacokinetics, Pharmacology +15

Pharmacokinetics and Pharmacodynamics of Alfentanil in P-Glycoprotein-Competent and P-Glycoprotein-Deficient Mice: P-Glycoprotein Efflux Alters Alfentanil Brain Disposition and Antinociception

J. Cory Kalvass, Emily R. Olson, Gary M. Pollack · Drug Metabolism and Disposition · 2006 · 25 citations

Medicine, Pharmacokinetics, Pharmacology +17