Pharmacokinetics and Pharmacodynamics of Alfentanil in P-Glycoprotein-Competent and P-Glycoprotein-Deficient Mice: P-Glycoprotein Efflux Alters Alfentanil Brain Disposition and Antinociception

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

Carlos Cordon‐Cardo, James P. O’Brien, João Paulo Boccia et al. · Journal of Histochemistry & Cytochemistry · 1990 · 1.1K citations

Medicine, Molecular Biology, Oncology +14

Isolation and expression of a complementary DNA that confers multidrug resistance

Philippe Gros, Yinon Ben Neriah, James M. Croop et al. · Nature · 1986 · 805 citations

Life Sciences, Genetics, Molecular Biology +12