Wenji Yin

Discovery of <i>N</i>-[(1<i>S</i>,2<i>S</i>)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity

Linus S. Lin, Thomas J. Lanza, James P. Jewell et al. · Journal of Medicinal Chemistry · 2006 · 122 citations · Full text

Cannabis Use, Molecular Pharmacology, Medicinal Chemistry +15

Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques

Koppara Samuel, Wenji Yin, Ralph A. Stearns et al. · Journal of Mass Spectrometry · 2003 · 77 citations

Hit Identification, Metabolic Activation, Metabolomic Profiling +17

Discovery of<i>N</i>-{(1<i>S</i>,2<i>S</i>)-2-(3-Cyanophenyl)- 3-[4-(2-[¹⁸F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a Cannabinoid-1 Receptor Positron Emission Tomography Tracer Suitable for Clinical Use

Ping Liu, Linus S. Lin, Terence G. Hamill et al. · Journal of Medicinal Chemistry · 2007 · 36 citations · Full text

Drug Target, Engineering, Cannabinoid Pharmacology +21

Conversion of the 2,2,6,6-Tetramethylpiperidine Moiety to a 2,2-Dimethylpyrrolidine by Cytochrome P450:  Evidence for a Mechanism Involving Nitroxide Radicals and Heme Iron

Wenji Yin, Kaushik Mitra, Ralph A. Stearns et al. · Biochemistry · 2004 · 27 citations

A Novel P450-Catalyzed Transformation of the 2,2,6,6-Tetramethyl Piperidine Moiety to a 2,2-Dimethyl Pyrrolidine in Human Liver Microsomes: Characterization by High Resolution Quadrupole-Time-of-Flight Mass Spectrometry and 1H-NMR

Wenji Yin, George A. Doss, Ralph A. Stearns et al. · Drug Metabolism and Disposition · 2003 · 15 citations