Laura McDowell

Abstract 526: RMC-9805, a first-in-class, mutant-selective, covalent and oral KRASG12D(ON) inhibitor that induces apoptosis and drives tumor regression in preclinical models of KRASG12D cancers

Lingyan Jiang, Marie Ménard, Caroline E. Weller et al. · Cancer Research · 2023 · 61 citations

Oral Krasg12d, Tumor Biology, Krasg12d Nsclc +13

The 5-Hydroxytryptamine4 Receptor Agonists Prucalopride and PRX-03140 Increase Acetylcholine and Histamine Levels in the Rat Prefrontal Cortex and the Power of Stimulated Hippocampal θ Oscillations

David E. Johnson, Elena M. Drummond, Sarah Grimwood et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 57 citations

Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors

Michelle M. Claffey, Christopher J. Helal, Patrick R. Verhoest et al. · Journal of Medicinal Chemistry · 2012 · 55 citations · Full text

Drug Target, Synaptic Transmission, Neurochemical Biomarkers +28

Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia

Christopher J. Helal, Zhijun Kang, Xinjun Hou et al. · Journal of Medicinal Chemistry · 2011 · 52 citations · Full text

Combinatorial Chemistry, Drug Target, Molecular Biology +21

Cloning and Functional Characterization of an NAD ⁺ -Dependent DNA Ligase from <i>Staphylococcus aureus</i>

Frank S. Kaczmarek, Richard P. Zaniewski, Thomas D. Gootz et al. · Journal of Bacteriology · 2001 · 51 citations · Full text