Concepedia

The 5-Hydroxytryptamine4 Receptor Agonists Prucalopride and PRX-03140 Increase Acetylcholine and Histamine Levels in the Rat Prefrontal Cortex and the Power of Stimulated Hippocampal θ Oscillations

David E. Johnson, Elena M. Drummond, Sarah Grimwood, Aarti Sawant‐Basak, Emily Miller, Elaine Tseng, Laura McDowell, Michelle Vanase‐Frawley, Katherine Fisher, David M. Rubitski,

Journal of Pharmacology and Experimental Therapeutics · 2012 · 57 citations · 40 references

DOI

Concepts

References

40

A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system.

Aline Dumuis, Rochdi Bouhelal, Michèle Sebben et al. · Molecular Pharmacology · 1988 · 438 citations

, , +13

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery

J. Cory Kalvass, Tristan S. Maurer · Biopharmaceutics & Drug Disposition · 2002 · 415 citations

, , +15

The 5‐HT4 receptor: molecular cloning and pharmacological characterization of two splice variants.

Christophe Gerald, Nika Adham, Hung‐Teh Kao et al. · The EMBO Journal · 1995 · 246 citations · Full text

, , +12

5‐Hydroxytryptamine (5‐HT)<sub>4</sub> receptors in <i>post mortem</i> human brain tissue: distribution, pharmacology and effects of neurodegenerative diseases

Gavin P. Reynolds, Sarah Mason, A. Meldrum et al. · British Journal of Pharmacology · 1995 · 198 citations · Full text

, , +17

Novel Brain-Specific 5-HT4 Receptor Splice Variants Show Marked Constitutive Activity: Role of the C-Terminal Intracellular Domain

Sylvie Claeysen, Michèle Sebben, Carine Bécamel et al. · Molecular Pharmacology · 1999 · 187 citations

, , +12