Bruce M. Bechle

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia

Amy B. Dounay, Marie Anderson, Bruce M. Bechle et al. · ACS Medicinal Chemistry Letters · 2012 · 88 citations · Full text

Kat Ii, Medicinal Chemistry, Biochemistry +13

Discovery of Clinical Candidate 4-[2-(5-Amino-1<i>H</i>-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-<i>N</i>-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na_V1.7

Nigel A. Swain, D. V. Batchelor, Serge Beaudoin et al. · Journal of Medicinal Chemistry · 2017 · 82 citations · Full text

Benzyloxazolidine-2,4-diones as potent hypoglycemic agents

Robert L. Dow, Bruce M. Bechle, Thomas T. Chou et al. · Journal of Medicinal Chemistry · 1991 · 60 citations

Metabolic Syndrome, Benzofuran Structural Element, Biochemistry +12

A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19

Charlotte Allerton, Joel T. Arcari, Lisa Aschenbrenner et al. · Journal of Medicinal Chemistry · 2024 · 59 citations · Full text

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists

Paul S. Humphries, John W. Benbow, Paul D. Bonin et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 51 citations · Full text

Biochemistry, G Protein-coupled Receptor, Medicine +5