Timothy Machajewski

The Catalytic Asymmetric Aldol Reaction

Timothy Machajewski, Chi‐Huey Wong · Angewandte Chemie International Edition · 2000 · 858 citations

Natural Sciences, Chemistry, Biocatalysis +13

Directed evolution of D-2-keto-3-deoxy-6-phosphogluconate aldolase to new variants for the efficient synthesis of D- and L-sugars

Sun Fong, Timothy Machajewski, Chi Ching Mak et al. · Chemistry & Biology · 2000 · 154 citations · Full text

Engineering, Biochemistry, Biotechnology +12

Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors

Paul A. Renhowe, Sabina Pecchi, Cynthia M. Shafer et al. · Journal of Medicinal Chemistry · 2008 · 135 citations · Full text

Medicine, Oncology, Pharmacology +13

The Novel Oral Hsp90 Inhibitor NVP-HSP990 Exhibits Potent and Broad-spectrum Antitumor Activities <i>In Vitro</i> and <i>In Vivo</i>

Daniel L. Menezes, Pietro Taverna, Michael Rugaard Jensen et al. · Molecular Cancer Therapeutics · 2012 · 86 citations

Medicine, Oncology, Pharmacology +8

One-Pot Synthesis of <scp>l</scp>-Fructose Using Coupled Multienzyme Systems Based on Rhamnulose-1-phosphate Aldolase

Dirk Franke, Timothy Machajewski, Che‐Chang Hsu et al. · The Journal of Organic Chemistry · 2003 · 81 citations

Life Sciences, Biochemistry, Biotechnology +14