Jennifer Castro

Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

Justin A. Caravella, Jian Lin, R. Bruce Diebold et al. · Journal of Medicinal Chemistry · 2020 · 132 citations · Full text

A Novel Mode of Protein Kinase Inhibition Exploiting Hydrophobic Motifs of Autoinhibited Kinases

Sudharshan Eathiraj, Rocio Palma, Marscha Hirschi et al. · Journal of Biological Chemistry · 2011 · 61 citations · Full text

Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors

Jian Lin, Wei Lu, Justin A. Caravella et al. · Journal of Medicinal Chemistry · 2019 · 46 citations · Full text

FT-6876, a Potent and Selective Inhibitor of CBP/p300, is Active in Preclinical Models of Androgen Receptor-Positive Breast Cancer

Maureen Caligiuri, Grace L. Williams, Jennifer Castro et al. · Targeted Oncology · 2023 · 29 citations · Full text

Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN)

Matthew W. Martin, David R. Lancia, Hongbin Li et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 18 citations · Full text

Combinatorial Chemistry, Lipid Synthesis, Biochemistry +6