A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

Longchuan Bai, Haibin Zhou, Renqi Xu, +15

Cancer Cell

Cancer ResearchMedicineSmall MoleculesSelective Small-molecule DegraderTumor Targeting +7

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

Wei Li, Takashi Tanikawa, Ilona Kryczek, +15

Cell Metabolism

Tumor BiologyBreast OncologyOncologyMedicineImmunology +9

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

Dmitry Borkin, Shihan He, Hongzhi Miao, +20

Cancer Cell

Hematological MalignancyMll LeukemiaPharmacologic InhibitionMedicineMixed-phenotype Acute Leukemia +7

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Bing Zhou, Jiantao Hu, Fuming Xu, +12

Journal of Medicinal Chemistry

Electron optics with p-n junctions in ballistic graphene

Shao-Wen Chen, Zheng Han, Mirza M. Elahi, +9

Science

Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

Oren Rom, Yuhao Liu, Zhipeng Liu, +30

Science Translational Medicine

Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

Chong Qin, Yang Hu, Bing Zhou, +21

Journal of Medicinal Chemistry

Molecular BiologyBet ProteinsBet InhibitorsTumor BiologyMedicinal Chemistry +20

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

Szymon Kłossowski, Hongzhi Miao, Katarzyna Kempińska, +32

Journal of Clinical Investigation

Npm1-mutated ModelsHematological MalignancySystems BiologyMixed LineageMixed-phenotype Acute Leukemia +11

Coronavirus Infections in the Central Nervous System and Respiratory Tract Show Distinct Features in Hospitalized Children

Yuanyuan Li, Haipeng Li, Ruyan Fan, +11

Intervirology

Evidence for a fractional fractal quantum Hall effect in graphene superlattices

Lei Wang, Yuanda Gao, Bo Wen, +6

Science