Mahesh P. Gupta

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

Nagalingam R. Sundaresan, Madhu Gupta, Gene Kim et al. · Journal of Clinical Investigation · 2009 · 985 citations · Full text

Life Sciences, Molecular Biology, Physiology +17

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

Nagalingam R. Sundaresan, Sadhana Samant, Vinodkumar B. Pillai et al. · Molecular and Cellular Biology · 2008 · 533 citations

Life Sciences, Biochemistry, Molecular Biology +16

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Nagalingam R. Sundaresan, Prabhakaran Vasudevan, Lei Zhong et al. · Nature Medicine · 2012 · 475 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

Vinodkumar B. Pillai, Sadhana Samant, Nagalingam R. Sundaresan et al. · Nature Communications · 2015 · 435 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

Sadhana Samant, Hannah J. Zhang, Zhigang Hong et al. · Molecular and Cellular Biology · 2013 · 428 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17