Mahesh P. Gupta

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

Nagalingam R. Sundaresan, Madhu Gupta, Gene Kim et al. · Journal of Clinical Investigation · 2009 · 982 citations · Full text

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

Nagalingam R. Sundaresan, Sadhana Samant, Vinodkumar B. Pillai et al. · Molecular and Cellular Biology · 2008 · 531 citations

Only Sirtuin, Stress-mediated Cell Death, Apoptosis +18

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Nagalingam R. Sundaresan, Prabhakaran Vasudevan, Lei Zhong et al. · Nature Medicine · 2012 · 470 citations · Full text

Cardiac Muscle, Cardiomyopathy, Molecular Physiology +9

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

Vinodkumar B. Pillai, Sadhana Samant, Nagalingam R. Sundaresan et al. · Nature Communications · 2015 · 429 citations · Full text

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

Vinodkumar B. Pillai, Nagalingam R. Sundaresan, Gene Kim et al. · Journal of Biological Chemistry · 2009 · 422 citations · Full text