Parker L. Sulkowski

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Parker L. Sulkowski, Christopher D. Corso, Nathaniel D. Robinson et al. · Science Translational Medicine · 2017 · 550 citations

Genetics, Molecular Biology, Molecular Genetics +19

Oncometabolites suppress DNA repair by disrupting local chromatin signalling

Parker L. Sulkowski, Sebastian Oeck, Jonathan Dow et al. · Nature · 2020 · 293 citations · Full text

Chromatin, Genome Instability, Dna Damage +9

Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

Parker L. Sulkowski, Ranjini K. Sundaram, Sebastian Oeck et al. · Nature Genetics · 2018 · 212 citations

Chromatin, Genome Instability, Dna Damage +12

In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery

Raman Bahal, Nicole McNeer, Elias Quijano et al. · Nature Communications · 2016 · 180 citations · Full text

Mitochondrial DNA stress signalling protects the nuclear genome

Zheng Wu, Sebastian Oeck, A. Phillip West et al. · Nature Metabolism · 2019 · 129 citations · Full text

Chromatin, Mitochondrial Biogenesis, Mitochondrial Function +7