Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

Satoshi Tsukada, Douglas C. Saffran, David J. Rawlings, +11

Cell

Autoimmune DiseaseReceptor Tyrosine KinaseMalignant Blood DisorderDeficient ExpressionHematology +6

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

David J. Rawlings, Douglas C. Saffran, Satoshi Tsukada, +9

Science

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.

Sandra J. Saouaf, S Mahajan, R. Rowley, +6

Proceedings of the National Academy of Sciences

Immune ActivationImmunologyAntigen ProcessingImmunotherapyReceptor Tyrosine Kinase +16

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

Satoshi Tsukada, Melvin I. Simon, Owen N. Witte, +1

Proceedings of the National Academy of Sciences

Molecular RegulationMolecular BiologyDefective GeneMolecular PharmacologySignaling Pathway +17

Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking.

Yuko Kawakami, Libo Yao, Tsuyoshi Miura, +3

Molecular and Cellular Biology

Molecular RegulationMast Cell DisorderImmunologyMolecular BiologyImmunologic Mechanism +19

Identification of the SH2 Domain Binding Protein of Bruton’s Tyrosine Kinase as BLNK—Functional Significance of Btk-SH2 Domain in B-Cell Antigen Receptor-Coupled Calcium Signaling

S. Hashimoto, Akihiro Iwamatsu, Masamichi Ishiai, +7

Blood

Activation of bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain

Tianjian Li, Satoshi Tsukada, Anne B. Satterthwaite, +4

Immunity

Pleckstrin HomologySignal TransductionSignaling PathwayReceptor Tyrosine KinaseTyrosine Kinase +6

IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.

Sinichi Sato, Takuya Katagiri, Yukiko Kikuchi, +7

The Journal of Experimental Medicine

ImmunologyImmune RegulationImmunologic MechanismInflammationSignaling Pathway +20

Deficient expression of Bruton's tyrosine kinase in monocytes from X-linked agammaglobulinemia as evaluated by a flow cytometric analysis and its clinical application to carrier detection.

Takeshi Futatani, Toshio Miyawaki, Satoshi Tsukada, +12

PubMed

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

Tomoki Matsuda, Mariko Takahashi-Tezuka, Toshiyuki Fukada, +7

Blood