Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

Makiko Mochizuki‐Kashio, Kazumasa Aoyama, Goro Sashida, +5

Blood

Cost-effective gene transfection by DNA compaction at pH 4.0 using acidified, long shelf-life polyethylenimine

Yasunori Fukumoto, Yuuki Obata, Kenichi Ishibashi, +7

Cytotechnology

Dna NanotechnologyEngineeringBiotechnologyGenetic EngineeringMolecular Biology +10

Dual inhibition of EZH1/2 breaks the quiescence of leukemia stem cells in acute myeloid leukemia

Shuhei Fujita, Daisuke Honma, Nobuaki Adachi, +8

Leukemia

Hematological MalignancyChromatinDual InhibitionMedicineAcute Myeloid Leukemia +10

The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition

Goro Sashida, Changshan Wang, T. Tomioka, +7

The Journal of Experimental Medicine

ImmunologyPathologyCancer BiologyEpigeneticsTumor Biology +14

Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition

Ola Rizq, Naoya Mimura, Motohiko Oshima, +12

Clinical Cancer Research

Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator

Takuro Kameda, Kotaro Shide, Takumi Yamaji, +22

Blood

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Shuhei Koide, Motohiko Oshima, Keiyo Takubo, +16

Blood

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

Naoki Itokawa, Motohiko Oshima, Shuhei Koide, +9

Nature Communications

Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies

Tomoyuki Tanaka, Yaeko Nakajima‐Takagi, Kazumasa Aoyama, +12

The Journal of Experimental Medicine

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome

Shiro Tara, Yusuke Isshiki, Yaeko Nakajima‐Takagi, +12

Blood