Nobuaki Adachi

Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas

Makoto Yamagishi, Makoto Hori, Dai Fujikawa et al. · Cell Reports · 2019 · 185 citations · Full text

Life Sciences, Cancer Biology, Oncology +17

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma

Koji Izutsu, Shinichi Makita, Kisato Nosaka et al. · Blood · 2022 · 156 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor

Daisuke Honma, Osamu Kanno, Jun Watanabe et al. · Cancer Science · 2017 · 139 citations · Full text

Medicine, Molecular Biology, Oncology +17

A human homologue of yeast anti‐silencing factor has histone chaperone activity

Tsubasa Munakata, Nobuaki Adachi, Natsuko Yokoyama et al. · Genes to Cells · 2000 · 137 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Dual inhibition of EZH1/2 breaks the quiescence of leukemia stem cells in acute myeloid leukemia

Shuhei Fujita, Daisuke Honma, Nobuaki Adachi et al. · Leukemia · 2017 · 100 citations

Medicine, Molecular Biology, Oncology +16