Michael G. Darcy

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Steven D. Knight, Nicholas D. Adams, Joelle L. Burgess et al. · ACS Medicinal Chemistry Letters · 2010 · 372 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

Aidan G. Gilmartin, Thomas Faitg, Mark C. Richter et al. · Nature Chemical Biology · 2014 · 208 citations

Life Sciences, Biochemistry, Molecular Biology +14

Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase

Dashyant Dhanak, Kevin J. Duffy, Victor K. Johnston et al. · Journal of Biological Chemistry · 2002 · 196 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

3-(1,1-Dioxo-2<i>H</i>-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1<i>H</i>)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

Rosanna Tedesco, Antony N. Shaw, Ramesh Bambal et al. · Journal of Medicinal Chemistry · 2006 · 160 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification of Potent, Selective Non-peptide CC Chemokine Receptor-3 Antagonist That Inhibits Eotaxin-, Eotaxin-2-, and Monocyte Chemotactic Protein-4-induced Eosinophil Migration

John R. White, Judithann M. Lee, Kimberly Dede et al. · Journal of Biological Chemistry · 2000 · 122 citations · Full text

Life Sciences, Immunology, Pharmacology +17