Patrick Yan

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

Omar Khan, Josephine R. Giles, Sierra McDonald et al. · Nature · 2019 · 1.5K citations

Transcriptional Regulation, T-regulatory Cell, Gene Expression +3

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

Jean‐Christophe Beltra, Sasikanth Manne, Mohamed S. Abdel-Hakeem et al. · Immunity · 2020 · 974 citations · Full text

Chromatin, Transcriptional Regulation, Lineage Plasticity +11

A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma

Alexander C. Huang, Robert Orlowski, Xiaowei Xu et al. · Nature Medicine · 2019 · 683 citations

Neoadjuvant Pd-1 Blockade, Surgical Oncology, Medicine +11

Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics

Josephine R. Giles, Shin Foong Ngiow, Sasikanth Manne et al. · Nature Immunology · 2022 · 222 citations · Full text

Chromatin, Functional Genomics, Single Cell Sequencing +12

A Phosphetane Catalyzes Deoxygenative Condensation of α-Keto Esters and Carboxylic Acids via P^III/P^V═O Redox Cycling

Wei Zhao, Patrick Yan, Alexander T. Radosevich · Journal of the American Chemical Society · 2015 · 158 citations

Chemical Engineering, Carboxylic Acids, Engineering +15