Natalie Hosea

Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs.

F. Peter Guengerich, Natalie Hosea, A Parikh et al. · PubMed · 1998 · 67 citations

Medicine, Biochemistry, Pharmacology +15

Prediction of Oral Pharmacokinetics Using a Combination of In Silico Descriptors and In Vitro ADME Properties

Yohei Kosugi, Natalie Hosea · Molecular Pharmaceutics · 2021 · 67 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +15

Predicting Pharmacokinetic Profiles Using <i>in Silico</i> Derived Parameters

Natalie Hosea, Hannah M. Jones · Molecular Pharmaceutics · 2013 · 64 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Direct Comparison of Total Clearance Prediction: Computational Machine Learning Model versus Bottom-Up Approach Using In Vitro Assay

Yohei Kosugi, Natalie Hosea · Molecular Pharmaceutics · 2020 · 51 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease

Christopher J. Helal, Zhijun Kang, John C. Lucas et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 48 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13