John C. Lucas

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease

Christopher J. Helal, Mark A. Sanner, Christopher B. Cooper et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 99 citations · Full text

Drug Target, Alzheimer's Disease, Biochemistry +10

Telescoped Flow Process for the Syntheses of <i>N</i>-Aryl Pyrazoles

Bryan Li, Daniel W. Widlicka, Steven J. Boucher et al. · Organic Process Research & Development · 2012 · 58 citations

N-aryl Pyrazole, Chemical Engineering, Engineering +9

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease

Christopher J. Helal, Zhijun Kang, John C. Lucas et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 47 citations · Full text

Molecular Pharmacology, Drug Target, Alzheimer's Disease +12

Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Kim Huard, Scott W. Bagley, Elnaz Menhaji‐Klotz et al. · The Journal of Organic Chemistry · 2012 · 33 citations

Medicinal Chemistry, Parham-type Cyclization, Biochemistry +12

A Concise and Regioselective Synthesis of 1-Alkyl-4-imidazolecarboxylates

Christopher J. Helal, John C. Lucas · Organic Letters · 2002 · 28 citations