Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

Daqing Sun, Zhihong Li, Yosup Rew, +46

Journal of Medicinal Chemistry

Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction

Yosup Rew, Daqing Sun, Felix González-López de Turiso, +32

Journal of Medicinal Chemistry

The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

Jude Canon, Tao Osgood, Steven H. Olson, +14

Molecular Cancer Therapeutics

Amg 232Tumor BiologyP53-inducing Cytotoxic AgentsMdm2-p53 InteractionMedicine +11

SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase

Jay P. Powers, Derek E. Piper, Yang Li, +11

Journal of Medicinal Chemistry

Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction

Ana Z. González, John Eksterowicz, Michael D. Bartberger, +33

Journal of Medicinal Chemistry

Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors

Felix González-López de Turiso, Daqing Sun, Yosup Rew, +27

Journal of Medicinal Chemistry

Potent Mdm2 InhibitorsDrug TargetMolecular BiologyTumor BiologyMolecular Pharmacology +15

Electroacupuncture improves swallowing function in a post-stroke dysphagia mouse model by activating the motor cortex inputs to the nucleus tractus solitarii through the parabrachial nuclei

Lulu Yao, Qiuping Ye, Yun Liu, +13

Nature Communications

Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres

Ana Z. González, Zhihong Li, Hilary P. Beck, +31

Journal of Medicinal Chemistry

Medicinal ChemistryMdm2-p53 InteractionDrug TargetBiochemistryNatural Sciences +13

Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction

Yosup Rew, Daqing Sun, Xuelei Yan, +32

Journal of Medicinal Chemistry

Drug TargetChemoprevention StrategyChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +18

Formation of DNA Adducts and Oxidative Base Damage by Copper Mediated Oxidation of Dopamine and 6-Hydroxydopamine

György Lévay, Qiuping Ye, William J. Bodell

Experimental Neurology

Dna DamageBiochemistryNatural SciencesCopper Mediated OxidationOxidative Base Damage +7