Kotoyo Isobe

Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA

Kazuto Nakada, Kimiko Inoue, Tomoko Ono et al. · Nature Medicine · 2001 · 416 citations

Mitophagy, Mitochondrial Transplantation, Mitochondrial Disease +12

Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria

Tomoko Ono, Kotoyo Isobe, Kazuto Nakada et al. · Nature Genetics · 2001 · 406 citations

Mitophagy, Mitochondrial Disease, Mitochondrial Function +12

Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes

Kimiko Inoue, Kazuto Nakada, Atsuo Ogura et al. · Nature Genetics · 2000 · 390 citations

Biology, Mouse Mtdna, Mitophagy +13

A new mitochondrial DNA mutation at 14577 T/C is probably a major pathogenic mutation for maternally inherited type 2 diabetes.

Masato Tawata, J Hayashi, Kotoyo Isobe et al. · Diabetes · 2000 · 70 citations · Full text

Metabolic Disorder, Genetics, Pathology +17

Complete Repopulation of Mouse Mitochondrial DNA-less Cells With Rat Mitochondrial DNA Restores Mitochondrial Translation but Not Mitochondrial Respiratory Function

Makiko Yamaoka, Kotoyo Isobe, Hiroshi Shitara et al. · Genetics · 2000 · 69 citations · Full text

Complete Repopulation, Mitochondrial Dysfunction, Genetics +17