Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes

A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies

Yu‐ichi Goto, Ikuya Nonaka, Satoshi Horai · Nature · 1990 · 2.1K citations

Life Sciences, Genetics, Molecular Genetics +11

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

Ian Holt, A. E. Harding, J A Morgan-Hughes · Nature · 1988 · 1.8K citations

Life Sciences, Genetics, Molecular Genetics +14

Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNALys mutation

John M. Shoffner, Marie T. Lott, Angela Maria Serena Lezza et al. · Cell · 1990 · 1.5K citations

Life Sciences, Genetics, Molecular Genetics +16

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

J Hayashi, Shigeo Ohta, Azusa Kikuchi et al. · Proceedings of the National Academy of Sciences · 1991 · 554 citations

Life Sciences, Genetics, Molecular Biology +17

Elimination of paternal mitochondrial DNA in intraspecific crosses during early mouse embryogenesis.

Hideki Kaneda, J Hayashi, S Takahama et al. · Proceedings of the National Academy of Sciences · 1995 · 466 citations

Life Sciences, Biology, Genetics +11