J Hayashi

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

J Hayashi, Shigeo Ohta, Azusa Kikuchi et al. · Proceedings of the National Academy of Sciences · 1991 · 554 citations · Full text

Mitochondrial Dysfunction, Genetics, Pathology +18

Elimination of paternal mitochondrial DNA in intraspecific crosses during early mouse embryogenesis.

Hideki Kaneda, J Hayashi, S Takahama et al. · Proceedings of the National Academy of Sciences · 1995 · 466 citations · Full text

Spermatogenesis, Sperm Midpiece, Cytogenetics +21

Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. Functional integrity of mitochondrial DNA from aged subjects.

J Hayashi, Shigeo Ohta, Y Kagawa et al. · Journal of Biological Chemistry · 1994 · 118 citations · Full text

Aging, Genetics, Molecular Biology +20

Functional and morphological abnormalities of mitochondria in human cells containing mitochondrial DNA with pathogenic point mutations in tRNA genes.

J Hayashi, Shigeo Ohta, Y Kagawa et al. · Journal of Biological Chemistry · 1994 · 79 citations · Full text

Mitophagy, Morphological Abnormalities, Genetics +19

Accumulation of mtDNA with a Mutation at Position 3271 in tRNALeu(UUR) Gene Introduced from a Melas Patient to HeLa Cells Lacking mtDNA Results in Progressive Inhibition of Mitochondrial Respiratory Function

J Hayashi, Shigeo Ohta, Daiya Takai et al. · Biochemical and Biophysical Research Communications · 1993 · 79 citations

Chromatin, Genome Instability, Mitochondrial Function +11