Velitchka Bontcheva-Diaz

ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

Cherrie K. Donawho, Yan Luo, Yanping Luo et al. · Clinical Cancer Research · 2007 · 773 citations · Full text

Medicine, Oncology, Pharmacology +15

Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(<i>R</i>)-2-methylpyrrolidin-2-yl]-1<i>H</i>-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer

Thomas D. Penning, Gui‐Dong Zhu, Viraj B. Gandhi et al. · Journal of Medicinal Chemistry · 2008 · 269 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

Thomas D. Penning, Gui‐Dong Zhu, Viraj B. Gandhi et al. · Bioorganic & Medicinal Chemistry · 2008 · 75 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Optimization of Phenyl-Substituted Benzimidazole Carboxamide Poly(ADP-Ribose) Polymerase Inhibitors: Identification of (<i>S</i>)-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1<i>H</i>-benzimidazole-4-carboxamide (A-966492), a Highly Potent and Efficacious Inhibitor

Gui‐Dong Zhu, Jianchun Gong, Sheela A. Thomas et al. · Journal of Medicinal Chemistry · 2010 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo.

Joann P. Palma, Luis E. Rodrı́guez, Velitchka Bontcheva-Diaz et al. · PubMed · 2008 · 56 citations

Medicine, Medicinal Chemistry, Pharmacology +14