Sheela A. Thomas

Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x _L from NMR and Parallel Synthesis

Andrew M. Petros, Jürgen Dinges, David J. Augeri et al. · Journal of Medicinal Chemistry · 2005 · 291 citations

Potent and selective inhibitors of Akt kinases slow the progress of tumors <i>in vivo</i>

Yan Luo, Alexander R. Shoemaker, Xuesong Liu et al. · Molecular Cancer Therapeutics · 2005 · 244 citations · Full text

Akt Kinases, Signal Transduction Pathways, Medicine +14

Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents

Yunsong Tong, Jennifer J. Bouska, Eric F. Johnson et al. · Journal of Medicinal Chemistry · 2009 · 108 citations · Full text

Small Molecule Inhibitors, Pharmaceutical Science, Bioorganic Chemistry +18

Synthesis of 1,3-Diynes via Palladium-Catalyzed Reaction of 1,1-Dibromo-1-alkenes

Shen Wang, Sheela A. Thomas · Organic Letters · 2000 · 81 citations

Unsymmetric 1,3-Diynes, Asymmetric Catalysis, Cross-coupling Reaction +11

Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors

Keith W. Woods, John P. Fischer, Akiyo Claiborne et al. · Bioorganic & Medicinal Chemistry · 2006 · 81 citations

Medicinal Chemistry, Medicine, Rational Drug Design +7