Viraj B. Gandhi

Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(<i>R</i>)-2-methylpyrrolidin-2-yl]-1<i>H</i>-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer

Thomas D. Penning, Gui‐Dong Zhu, Viraj B. Gandhi et al. · Journal of Medicinal Chemistry · 2008 · 264 citations · Full text

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

Thomas D. Penning, Gui‐Dong Zhu, Viraj B. Gandhi et al. · Bioorganic & Medicinal Chemistry · 2008 · 74 citations · Full text

Medicinal Chemistry, Biochemistry, Potent Inhibitor +8

Optimization of Phenyl-Substituted Benzimidazole Carboxamide Poly(ADP-Ribose) Polymerase Inhibitors: Identification of (<i>S</i>)-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1<i>H</i>-benzimidazole-4-carboxamide (A-966492), a Highly Potent and Efficacious Inhibitor

T.M. Penning, Gui‐Dong Zhu, Jianchun Gong et al. · Journal of Medicinal Chemistry · 2010 · 70 citations · Full text

Excellent Potency, Pharmaceutical Science, Pharmacotherapy +21

Design and synthesis of pyridine–pyrazolopyridine-based inhibitors of protein kinase B/Akt

Gui‐Dong Zhu, Jianchun Gong, Viraj B. Gandhi et al. · Bioorganic & Medicinal Chemistry · 2007 · 62 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Protein Kinase B/akt +11

Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension

Gui‐Dong Zhu, Viraj B. Gandhi, Jianchun Gong et al. · Journal of Medicinal Chemistry · 2007 · 62 citations · Full text

Pharmaceutical Science, Protein Kinase B/akt, Pharmacotherapy +16