Jianchun Gong

Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(<i>R</i>)-2-methylpyrrolidin-2-yl]-1<i>H</i>-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer

Thomas D. Penning, Gui‐Dong Zhu, Viraj B. Gandhi et al. · Journal of Medicinal Chemistry · 2008 · 269 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

Thomas D. Penning, Gui‐Dong Zhu, Viraj B. Gandhi et al. · Bioorganic & Medicinal Chemistry · 2008 · 75 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Optimization of Phenyl-Substituted Benzimidazole Carboxamide Poly(ADP-Ribose) Polymerase Inhibitors: Identification of (<i>S</i>)-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1<i>H</i>-benzimidazole-4-carboxamide (A-966492), a Highly Potent and Efficacious Inhibitor

Gui‐Dong Zhu, Jianchun Gong, Sheela A. Thomas et al. · Journal of Medicinal Chemistry · 2010 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Design and synthesis of pyridine–pyrazolopyridine-based inhibitors of protein kinase B/Akt

Gui‐Dong Zhu, Jianchun Gong, Viraj B. Gandhi et al. · Bioorganic & Medicinal Chemistry · 2007 · 62 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension

Gui‐Dong Zhu, Viraj B. Gandhi, Jianchun Gong et al. · Journal of Medicinal Chemistry · 2007 · 62 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16