Alessandro T. Caputo

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Richard A. Ward, C. Brassington, Alexander L. Breeze et al. · Journal of Medicinal Chemistry · 2012 · 169 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17

Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels

Oliver B. Clarke, Alessandro T. Caputo, Adam P. Hill et al. · Cell · 2010 · 151 citations · Full text

Natural Sciences, Biophysics, Molecular Biology +16

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals

Alessandro T. Caputo, Dominic S. Alonzi, Lucia Marti et al. · Proceedings of the National Academy of Sciences · 2016 · 94 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases—Not Glycolipid Processing Enzymes

Andrew C. Sayce, Dominic S. Alonzi, Sarah S. Killingbeck et al. · PLoS neglected tropical diseases · 2016 · 84 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +13

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

Kelly L. Warfield, Emily M. Plummer, Andrew C. Sayce et al. · Antiviral Research · 2016 · 70 citations · Full text

Medicine, Infectious Diseases, Pharmacology +15