Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases—Not Glycolipid Processing Enzymes

Andrew C. Sayce, Dominic S. Alonzi, Sarah S. Killingbeck, +13

PLoS neglected tropical diseases

EngineeringMany IminosugarsGlycobiologyImmunologyImmunotherapeutics +17

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

Kelly L. Warfield, Emily M. Plummer, Andrew C. Sayce, +25

Antiviral Research

Liposome-Mediated Delivery of Iminosugars Enhances Efficacy against Dengue Virus <i>In Vivo</i>

Joanna L. Miller, Ruben Lachica, Andrew C. Sayce, +6

Antimicrobial Agents and Chemotherapy

ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum α-Glucosidase II Exhibiting Antiflaviviral Activity

J. L. Kiappes, Michelle L. Hill, Dominic S. Alonzi, +6

ACS Chemical Biology

Viral ImmunityImmunologyBiological TherapyImmunotherapeuticsInnate Immunity +21

Reverse iontophoresis of urea in health and chronic kidney disease: a potential diagnostic and monitoring tool?

Leonard Ebah, Ian Read, Andrew C. Sayce, +4

European Journal of Clinical Investigation

Extra-glycosomal localisation of Trypanosoma brucei hexokinase 2

April C. Joice, Todd Lyda, Andrew C. Sayce, +5

International Journal for Parasitology

Parasitic ProtozoaAfrican TrypanosomiasisPathogenesisHistopathologyExtra-glycosomal Localisation +4

Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model

Joanna L. Miller, Simon Spiro, Stuart Dowall, +11

PLoS ONE

VaccinationSmall Animal ModelsMucosal VaccinationVeterinary VaccinePotent Iminosugars +13

Iminosugars counteract the downregulation of the interferon γ receptor by dengue virus

Joanna L. Miller, Michelle L. Hill, Juliane Brun, +3

Antiviral Research

Dengue VirusMicrobial PathogensPrimary MacrophagesViral PathogenesisImmunology +14

Pathogen‐induced inflammation is attenuated by the iminosugar M<i>O</i>N‐DNJ via modulation of the unfolded protein response

Andrew C. Sayce, Fernando O. Martínez, Beatrice E. Tyrrell, +5

Immunology