A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal

Michael Milyavsky, Olga I. Gan, Magan Trottier, +11

Cell stem cell

Genome InstabilityDna DamageMedicineApoptosisApoptosis-independent Role +7

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma

Laura Donovan, Alberto Delaidelli, Sujith K. Joseph, +53

Nature Medicine

Neuro-oncologyCar T CellsCerebrospinal FluidLocoregional DeliverySurgery +3

DNA hypermethylation within TERT promoter upregulates TERT expression in cancer

Donghyun D. Lee, Ricardo Leão, Martin Komosa, +33

Journal of Clinical Investigation

Epigenetic ChangeGeneticsDna MethylationMolecular BiologyEpigenetics +16

DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells

Jiil Chung, Yosef E. Maruvka, Sumedha Sudhaman, +52

Cancer Discovery

Combined genetic and epigenetic alterations of the <i>TERT</i> promoter affect clinical and biological behavior of bladder cancer

Ricardo Leão, Donghyun Lee, Arnaldo Figueiredo, +27

International Journal of Cancer

K63-Ubiquitylation of VHL by SOCS1 mediates DNA double-strand break repair

Julie Metcalf, Paul S. Bradshaw, Martin Komosa, +3

Oncogene

ChromatinGenome InstabilityNatural SciencesMolecular BiologyDna Replication +5

FANCD2 limits BLM-dependent telomere instability in the alternative lengthening of telomeres pathway

Heather Root, Andrew Larsen, Martin Komosa, +4

Human Molecular Genetics

ChromatinGenome InstabilityFanconi AnemiaBlm-dependent Telomere InstabilityGenetic Disorder +13

Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition

Brittany Campbell, Melissa A. Galati, Simone C. Stone, +26

Cancer Discovery

Genomic Microsatellite Signatures Identify Germline Mismatch Repair Deficiency and Risk of Cancer Onset

Jiil Chung, Logine Negm, Vanessa Bianchi, +44

Journal of Clinical Oncology

Syndecan contributes to heart cell specification and lumen formation during Drosophila cardiogenesis

Jessica Knox, Katherine Ellen Moyer, Nasrine Yacoub, +10

Developmental Biology

Developmental BiologySignal TransductionDrosophila CardiogenesisSyndecan ContributesDevelopmental Genetics +9