A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

Haiwei Chen, Phu-Khat Nwe, Yi Yang, +8

Cell

BiologyModulate Host PhysiologyMicrobiota FunctionDysbiosisHost-microbe Interactions +9

A reservoir of stem-like CD8 ⁺ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response

Kelli A. Connolly, Manik Kuchroo, Aarthi Venkat, +19

Science Immunology

Common Risk Alleles for Inflammatory Diseases Are Targets of Recent Positive Selection

Towfique Raj, Manik Kuchroo, Joseph M. Replogle, +3

The American Journal of Human Genetics

InflammationDisease SusceptibilityAllelic VariantCommon Risk AllelesAutoimmune Disease +12

Structural and developmental principles of neuropil assembly in C. elegans

Mark W. Moyle, Kristopher M Barnes, Manik Kuchroo, +16

Nature

BiologyPattern FormationDevelopmental BiologyDevelopmental GeneticsMedicine +6

Multiscale PHATE identifies multimodal signatures of COVID-19

Manik Kuchroo, Jessie Huang, Patrick Wong, +18

Nature Biotechnology

Multiscale Phate IdentifiesViral DiagnosticsCovid-19 PandemicMolecular BiologyVirology +4

Single-cell analysis reveals inflammatory interactions driving macular degeneration

Manik Kuchroo, Marcello DiStasio, Eric Song, +22

Nature Communications

An RNA Profile Identifies Two Subsets of Multiple Sclerosis Patients Differing in Disease Activity

Linda Ottoboni, Brendan T Keenan, Pablo Tamayo, +7

Science Translational Medicine

NeurogenomicsDisease ProgressionNeurological DisorderImmunodeficienciesImmunology +25

Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor–induced diabetes

Ana Luisa Perdigoto, Songyan Deng, Katherine Du, +17

JCI Insight

Immune RegulationImmunologyCell DeathCheckpoint Ligand ExpressionImmunologic Mechanism +24

Manifold Interpolating Optimal-Transport Flows for Trajectory Inference.

Guillaume Huguet, D S Magruder, Alexander Tong, +4

PubMed

Geometric LearningStatic Snapshot SamplesEngineeringMachine LearningData Science +12

Coarse Graining of Data via Inhomogeneous Diffusion Condensation

Nathan Brugnone, Alex Gonopolskiy, Mark W. Moyle, +7

Cluster ComputingGeometric LearningEngineeringData Affinity GraphUnsupervised Machine Learning +17