Young Kyuen Im

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

Laura Hulea, Simon‐Pierre Gravel, Masahiro Morita et al. · Cell Metabolism · 2018 · 85 citations · Full text

Metabolic Network, Signal Transduction, Biochemistry +9

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

Ryuhjin Ahn, Valérie Sabourin, Alicia M. Bolt et al. · Nature Communications · 2017 · 60 citations · Full text

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

Stephanie Totten, Young Kyuen Im, Eduardo Cepeda Cañedo et al. · Nature Communications · 2021 · 58 citations · Full text

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner

Young Kyuen Im, Rachel La Selva, Valentina Gandin et al. · Oncogene · 2014 · 25 citations · Full text

Angiogenesis, Signaling Pathway, Medicine +10

A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer

Regina Cencic, Young Kyuen Im, Sai Kiran Naineni et al. · Proceedings of the National Academy of Sciences · 2024 · 18 citations · Full text

Breast Oncology, Engineering, Mrna Translation +19